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Moreover, CR has been shown to protect against cognitive decline via upregulation of BDNF 30,39

[DOI] [PubMed] [Google Scholar] 13.Simon A, Wegrowski Y, Bontemps Y, et al

In their review of the evidence, FDA scientists flag potential safety concerns and a lack of consistent data

Prescription-strength azelaic acid is worth considering if you: Have persistent acne that hasnt responded well to OTC treatments Are dealing with rosacea especially inflammatory rosacea with redness, papules, or pustules Struggle with post-inflammatory hyperpigmentation (dark marks left behind after breakouts) Have been diagnosed with or suspect melasma Are pregnant or breastfeeding and need an effective acne or pigmentation treatment thats considered safe Have sensitive skin that hasnt tolerated retinoids, benzoyl peroxide, or other common actives Are looking for an antibiotic-free acne treatment option Its also worth knowing that prescription azelaic acid is frequently used in combination with other treatments retinoids, topical antibiotics, niacinamide as part of a comprehensive skincare regimen